Overview
Product name
Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitorDescription
Cell permeable, irreversible pan-caspase inhibitorAlternative names
- Z-VAD-FMK (cell permeable)
Biological description
A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required.
Purity
>90%CAS Number
187389-52-2Chemical structure
Properties
Molecular weight
467.49Molecular formula
C22H30FN3O7Sequence
VAD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Asp-3 = Asp(OMe))PubChem identifier
5497173Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overview
Soluble in DMSO to 20 mMHandling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
FCC(=O)C(CC(=O)OC)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)CSource
Synthetic
Research areas
- Cell Biology
- Apoptosis
- Intracellular
- Caspases etc
- Caspases
- Biochemicals
- Chemical Type
- Biochemicals
- Biochemicals
- Chemical Type
- Bioactive peptides
- Biochemicals
- Pharmacology
- Enzymes
- Caspase
- Biochemicals
- Pharmacology
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Heart disease
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Pain & inflammation
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Alzheimer"s Disease
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Alzheimer"s Disease
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Cancer
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Diabetes
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Heart disease
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Hypertension
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Obesity
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Obesity
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Pain & inflammation
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Respiratory disease
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Respiratory disease
- Signaling
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Stroke
- Apoptosis & cell cycle
- Caspase
- Biochemicals
- Research Area
- Stroke
- Signaling
- Apoptosis & cell cycle
- Caspase
