Description
Product name
Recombinant human PD1 protein (Active)See all PD1 proteins and peptidesBiological activity
Measured by its binding ability in a functional ELISA.
Immobilized PD1 at 10 μg/ml (100 μl/well) can bind recombinant Human B7-H1 Fc chimera with a linear range of 0.005- 0.4 μg/ml.
Purity
>95% SDS-PAGE.>90% as determined by SEC-HPLC.Endotoxin level
<>Expression system
HEK 293 cellsAccession
Q15116Protein length
Protein fragmentAnimal free
NoNature
RecombinantSpecies
HumanSequence
LDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQPredicted molecular weight
17 kDa including tagsAmino acids
25 to 167Tags
His tag C-TerminusAdditional sequence information
(NP_005009.2)
Associated products
Related Products
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-6X His tag® antibody (ab9108)
Specifications
Our Abpromise guarantee covers the use ofab174035in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Applications
HPLC
SDS-PAGE
Functional Studies
ELISA
Form
LyophilizedAdditional notes
For long term storage, store at lyophlized state at-20°C or lower. After reconstitution, store under sterile conditions for 3 months at -70°C or 12months at 4-8°C at lyophlized state. Avoid repeated freeze-thaw cycles.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -20°C or -80°C. Please see notes section.
pH: 7.40Constituents: PBS, 5% Trehalose
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- ReconstitutionIt is recommended to reconstitute the lyophilized protein with 500µL sterile deionized water to a stock solution of 200 µg/mL.
General Info
Alternative names
- CD279
- CD279 antigen
- hPD 1
see allFunction
Possible cell death inducer, in association with other factors.Involvement in disease
Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain.Developmental stage
Induced at programmed cell death.Cellular localization
Membrane.- Information by UniProt
