Overview
Product name
Dyngo® 4a, Novel, highly potentdynamin inhibitorDescription
Novel, highly potent dynamin inhibitor. Dynasore (ab120192) analog.Biological description
Novel, highly potent dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). Dynasore (ab120192) analog. Prevents botulin neurotoxin A (BoNTs) uptake and internalization, and prevents SNAP25 cleavage. Inhibits BoNTs induced paralysis and delays botulism onset.
General notes
Sold under exclusive licence from Children"s Medical Research Institute and Newcastle Innovation Ltd. Dyngo® is a trademark of Children"s Medical Research Institute and Newcastle Innovation Ltd.CAS Number
1256493-34-1Chemical structure
Properties
Chemical name
3-Hydroxy-N'-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
Molecular weight
338.31Molecular formula
C18H14N2O5PubChem identifier
136227923Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overview
Soluble in DMSO to 100 mM
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3O)O)O)OSource
Synthetic
Research areas
- Biochemicals
- Chemical Type
- Biochemicals
- Biochemicals
- Pharmacology
- Enzymes
- ATPase & GTPase
- Inhibitors
- Biochemicals
- Pharmacology
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Heart disease
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Pain & inflammation
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Alzheimer"s Disease
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Obesity
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Respiratory disease
- Signaling
- Endocytosis & exocytosis
- Dynamin
- Biochemicals
- Research Area
- Stroke
- Signaling
- Endocytosis & exocytosis
- Dynamin
