Overview
Product name
Phorbol 12-myristate 13-acetate (PMA), PKC activatorDescription
PKC activatorAlternative names
- PMA
Biological description
Potent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non-kinase proteins including chimaerins, RasGRP and Unc-13/Munc-13. Extremely potent mouse skin tumor promoter.
Purity
>99%CAS Number
16561-29-8Chemical structure
Properties
Chemical name
Phorbol 12-myristate 13-acetateMolecular weight
616.83Molecular formula
C36H56O8PubChem identifier
27924Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mMHandling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
CC(=O)O[C@@]43[C@H](OC(=O)CCCCCCCCCCCCC)[C@@H](C)[C@@]1(O)[C@@H](C=C(CO)C[C@]2(O)C(=O)C(C)=C[C@@H]12)[C@@H]4C3(C)CSource
Synthetic
Research areas
- Signal Transduction
- Protein Phosphorylation
- Ser / Thr Kinases
- PKC
- Neuroscience
- Neurology process
- Neuroendocrinology
- Prolactin
- Neuroscience
- Neurology process
- Neurodegenerative disease
- Other
- Cancer
- Signal transduction
- Protein phosphorylation
- Serine/threonine kinases
- MAPK pathway
- Cardiovascular
- Heart
- Hypertrophy
- Other
- Cancer
- Cancer Metabolism
- Metabolic signaling pathway
- Metabolism of lipids and lipoproteins
- Cancer
- Cancer Metabolism
- Response to hypoxia
- Biochemicals
- Chemical Type
- Biochemicals
- Biochemicals
- Pharmacology
- Enzymes
- Kinase
- Protein Kinase C
- Activators
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolism processes
- Hypoxia
- Metabolism
- Types of disease
- Obesity
