Abcam/Recombinant human CD47 protein (Fc Chimera Active) (ab220587)/1/Fc Chimera Active) (ab220587
品牌：
Abcam
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description
Product name
Recombinant human CD47 protein (Fc Chimera Active)See all CD47 proteins and peptidesBiological activity
Measured by its binding ability in a functional ELISA. Immobilized ab220587 at 2 μg/mL (100 μL/well) can bind Human SIRP alpha, His Tagwith a linear range of 0.016-0.5 μg/mL.
Purity
>95% SDS-PAGE.>90% as determined by SEC-HPLC.Endotoxin level
<>Expression system
HEK 293 cellsAccession
Q08722-3Protein length
Protein fragmentAnimal free
NoNature
RecombinantSpecies
HumanSequence
QLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTF DGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTE LTREGETIIELKYRVVSWFSPPredicted molecular weight
40 kDa including tagsAmino acids
19 to 139Tags
Fc tag C-TerminusAdditional sequence information
Fused with a human IgG1 Fc tag (Pro 100 - Lys 330; P01857) at the C-terminus (NP_942088).
Specifications
Our Abpromise guarantee covers the use ofab220587in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Applications
Functional Studies
SDS-PAGE
HPLC
Flow Cytometry
Form
Lyophilized
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.4Constituents: 0.61% Tris, 0.75% Glycine, 5% TrehaloseLyophilized from 0.22 µm filtered solution.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- ReconstitutionReconstitute with sterile deionized water to a concentration of 1 mg/ml.
General Info
Alternative names
- Antigen identified by monoclonal antibody 1D8
- Antigenic surface determinant protein OA3
- CD 47
see allFunction
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.Tissue specificity
Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain.Cellular localization
Cell membrane.- Information by UniProt
品牌介绍
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