Overview
Product name
DAPT, gamma-Secretase inhibitorDescription
γ-Secretase inhibitorBiological description
γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable.3D Growth matrix component and component of cerebral organoid differentiation media.
Purity
>99%CAS Number
208255-80-5Chemical structure
Properties
Chemical name
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-(S)-phenylglycine t-butyl esterMolecular weight
432.47Molecular formula
C23H26F2N2O4PubChem identifier
5311272Storage instructions
Store at +4°C. The product can be stored for up to 12 months.Solubility overview
Soluble in DMSO to 100 mMHandling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)FSource
Synthetic
Research areas
- Biochemicals
- Chemical Type
- Biochemicals
- Biochemicals
- Pharmacology
- Enzymes
- Secretase
- Inhibitors
- Biochemicals
- Pharmacology
- Signaling
- Stem Cells
- Other
