Overview
Product name
Calyculin A, protein phosphatase inhibitorDescription
Potent, selective and cell-permeable protein phosphatase inhibitorBiological description
Potent, selective and cell-permeable protein phosphatase inhibitor (IC50 values are 2 and 1 nM for PP1 and PP2A, respectively). Highly selective over PP2B and PP2C. Active in vivo and in vitro.
Purity
>99%CAS Number
101932-71-2Chemical structure
Properties
Chemical name
[(2R,3R,5R,7R,8S,9S)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraenyl]-9-[(E)-3-[2-[(2S)-4-[[(2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphateMolecular weight
1009.18Molecular formula
C50H81N4O15PPubChem identifier
5311365Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overview
Soluble in ethanol and in DMSOHandling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
CC1C(CC2(C(C(C(O2)C(CC(C(C)C(C(C)C=C(C)C(=CC=CC(=CC#N)C)C)O)O)OC)OP(=O)(O)O)(C)C)OC1CC=CC3=COC(=N3)C(C)CCNC(=O)C(C(C(COC)N(C)C)O)O)OSource
Discodermia calyx
Research areas
- Cell Biology
- Cell Cycle
- Kinases/Phosphatases
- Phosphatases
- Neuroscience
- Neurotransmission
- Intracellular Signaling
- Phosphatases
- Signal Transduction
- Protein Phosphorylation
- Tyrosine Phosphatases
- Signal Transduction
- Protein Phosphorylation
- Ser / Thr Phosphatases
- Signal Transduction
- Metabolism
- Vitamins / Minerals
- Cardiovascular
- Atherosclerosis
- Diabetes associated
- Cancer
- Cancer Metabolism
- Metabolic signaling pathway
- Metabolism of lipids and lipoproteins
- Biochemicals
- Product Range
- New
- Biochemicals
- Chemical Type
- Biochemicals
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Cofactors, Vitamins / minerals
- Vitamins / minerals
